Picayune is the largest city in Pearl River County, Mississippi. The population was 10,878 at the 2010 census. Picayune was added to the New Orleans Metropolitan area in 2014. Picayune is approximately 45 miles (72 km) from New Orleans, Hattiesburg, and Gulfport/Biloxi. The Stennis Space Center is 10 miles (16 km) away.